Gland
Zona reticularis
The inner cortical network supplying androgen precursors
High-yield
Adrenarche reflects increased adrenal androgen production and is distinct from activation of the gonadal axis. Peripheral tissues convert adrenal precursors into more active sex steroids.
Overview
The zona reticularis lies between the fasciculata and medulla. Its compact cells form an interconnecting network and produce DHEA, DHEAS and other androgen precursors. Development and activity of this zone change with age, including its expansion around adrenarche.
Reference facts
- Location
- Innermost cortical layer adjacent to the adrenal medulla.
- Hormones
- DHEA, DHEAS and androstenedione, with some glucocorticoid production.
- Blood supply
- Inner cortical sinusoids carry steroid-rich blood toward medullary channels.
- Innervation
- ACTH supports secretion, alongside age-dependent enzyme expression and local regulatory mechanisms.
- Function
- Provides circulating precursors for tissue androgen and estrogen production and contributes to pubic/axillary hair development at adrenarche.
Clinical correlation
21-hydroxylase deficiency can increase adrenal androgen production, but only severe forms cause major aldosterone deficiency and salt wasting. Adrenal androgen-secreting tumors may produce rapidly progressive androgenic changes, while normal adrenal androgen output tends to decline with aging.
Frequently asked questions
Where is the zona reticularis located?
The zona reticularis lies innermost cortical layer adjacent to the adrenal medulla.
What does the zona reticularis secrete?
The zona reticularis secretes DHEA, DHEAS and androstenedione, with some glucocorticoid production.
What does the zona reticularis do?
Provides circulating precursors for tissue androgen and estrogen production and contributes to pubic/axillary hair development at adrenarche.
What is the blood supply of the zona reticularis?
The zona reticularis is supplied by the inner cortical sinusoids carry steroid-rich blood toward medullary channels.